Applications

To download technical notes for the experiments in the table below, register and/or login for access.

Mixing
Liquid homogeneous	Equivalent to static mixer at 4 m/s
L/L	Equivalent to ½ litre batch at 400 rpm
G/L	> 1 l batch at 600 rpm
G/L/S	5 times better than 100 ml batch	see publication list
Liquid homogenous	Higher yield than 1 litre batch	see publication list
Heat transfer
Liquid homogenous	reaction time 8 times faster than 1 litre batch
L/S	Suzuki reaction 10 times faster than 1 litre batch
Solids
Solid formation	semicarbazone
Solids formation	Nanoparticle clusters
Solids formation	Carbon nanotubes	see publication list
Slurry	Enzyme free on whole cells
Solids formation	Grignard reaction
Solid formation	NaCl up to 25%
Slurry	PVA particles, 50-200 micron, up to 30%	video
Slurry	Alumina particle, 50-200 micron, up to 10%
Slurry	Caesium Carbonate 20-70 micron, up to 10%
Slurry	Sodium carbonate in DMF
Slurry	N-iodomorpholinium hydroiodide salt	see publication list
Crystallisations	Calcium carbonate, 3 polymorphs

 

List of reactions:
Biocatalytic oxidase
Hoffman reaction
Suzuki reaction
Bourne reaction
Nitration
Polymerizations
Grignard reactions
De-hydrogenations
Reaction using BuLi
Heterogeneous catalysis
Crystallisations
Oxidation Reaction
Ozonolosys
Counter current extractions

List of Publications:

Salice, P., et al., 2012, Efficient functionalization of carbon nanotubes: an opportunity enabled by flow chemistry, Chemistry Today, vol 60 n 6, pp 37-39

Ashe, R. and Dahlbeck R., 2012, Wie Sich Feststoffe in Durchflussreaktoren richtig handhaben lassen, Process.de

Ashe, R., 2012, Handling Solids in Flow Reactors, Speciality Chemicals Magazine, May, 28-29

Gasparini, G., et al., 2012, Scaling Up Bio Catalysis Reactions in Flow Reactors, Organic Process Research and Development, http://dx.doi.org/10.1021/op2003612

Jones, E., et al., 2012, Biocatalytic oxidase: Batch to continuous. Chem. Eng. Res. Des., doi:10.1016/j.cherd.2012.01.018

Browne, D.L., et al., Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor, Organic Process Research and Development, March 9 2011 , 15(3), pp 693-697

Ashe.R, 2010, Shaken not stirred, tce magazine July-August, 39-41

Gómez-Quero, S., et. al., 2011, Liquid phase catalytic hydrodechlorination of 2, 4-dichlorophenol over Pd/Al2O3: Batch vs. continuous operation, Chemical Engineering Journal, vol 166, issue 3, 1044-1051

Delogu, P., Gasparini, G., 2010, Scale up of Continuous Processes using multistage CSTR’s, Speciality Chemicals Magazine May, 34-35

Gasparini, G., Patel, M., 2009, Flow Reactors and Dynamic Mixing, Speciality Chemicals Magazine April, 22-23

Ashe, R., 2008, Continuous reactors with easy scale-up, Manufacturing Chemist Magazine September, 83-84

Ashe, R., Patel, M., 2008, Marrying efficiency with flexibility, tce magazine July. , 35-37